Symbol
Name
ID

Arhgef1
Rho guanine nucleotide exchange factor 1
MGI:1353510

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgG level

Decreased circulating total IgM

Reduced isohemagglutinin level

Complete or near-complete absence of specific antibody response to tetanus vaccine

Decreased proportion of memory B cells

Increased proportion of transitional B cells

B lymphocytopenia

Autoimmune thrombocytopenia

Recurrent upper respiratory tract infections

Recurrent lower respiratory tract infections

Severe recurrent varicella

Recurrent herpes

Disease(s) Associated with ARHGEF1

immunodeficiency 62

Mouse Phenotypes

decreased B cell proliferation

increased T cell proliferation

enlarged spleen

increased plasmacytoid dendritic cell number

decreased dendritic cell number

abnormal lymphocyte cell number

increased germinal center B cell number

decreased B-1 B cell number

decreased follicular B cell number

decreased marginal zone B cell number

decreased B cell number

increased KLRG1-positive NK cell number

decreased Ly6C-positive immature NK cell number

decreased immature NK cell number

increased mature NK cell number

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD4-positive, alpha-beta memory T cell number

increased CD4-positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta memory T cell number

decreased CD8-positive, alpha-beta T cell number

decreased memory-marker CD4-positive NK T cell number

increased Ly6C-positive NK T cell number

decreased memory-marker gamma-delta T cell number

increased gamma-delta T cell number

increased Ly6C low monocyte number

increased monocyte cell number

increased leukocyte cell number

abnormal neutrophil physiology

abnormal lymphocyte physiology

decreased IgG level

decreased IgM level

abnormal marginal zone B cell physiology

abnormal humoral immune response

Availability

Mouse Genotype

Arhgef1^tm1.1Rmt/Arhgef1^tm1.1Rmt

Arhgef1^{tm1a(EUCOMM)Wtsi}/Arhgef1^{tm1a(EUCOMM)Wtsi}

Arhgef1^tm1Djle/Arhgef1^tm1Djle

Arhgef1^tm1Kdf/Arhgef1^tm1Kdf

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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